The Battle of Landriano took place on 21 June 1529, between the French army under Francis de Bourbon, Comte de St. Pol and the Imperial–Spanish army commanded by Don Antonio de Leyva, Duke of Terranova in the context of the War of the League of Cognac. The French army was destroyed and marked the end of the ambitions of Francis I of France to vie for control of northern Italy with Charles V, Holy Roman Emperor.
In 1528 the Genoese Admiral, Andrea Doria, after deserting in favour of Emperor Charles V, managed to break up the French siege of Naples; his efforts were helped by the plague, which decimated the French besiegers, among them General Odet of Foix, Viscount of Lautrec, who died on 15 August. After his death, the French army was commanded by the Giovanni Ludovico of Saluzzo, who, under the circumstances ordered his troops to withdraw on 29 August, but eventually the Imperial–Spanish forces led by Philibert of Châlon, Prince of Orange, caught up with them and decimated them. Shortly after the whole French army in the south of Italy capitulated.
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