In 1034 the Baffo family built a church and a convent for Benedictine nuns, with the task to keep a holy image of St. Erasmus. The current name dates to 1237, when the relics of St. Secundus were brought here from Asti. In 1533 the Benedictines were replaced by Dominicans and in 1566 it became a lazzaretto. Starting from 1569, after a fire in the Venetian arsenal, the Republic of Venice moved a powder store here.
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