Materdomini is an Italian hamlet situated in the municipality of Caposele, Province of Avellino, Campania. As of 2009 its population was of 735.
Materdomini's name, a Latin word meaning Mother of God, derives from an ancient chapel dedicated to Santa Maria Materdomini, first mentioned in 1500. On October 16, 1755, Gerard Majella died in this chapel and was buried there. He was canonized in 1904. Mainly for this reason, during the first half of the 20th century, it grew into a village in the neighborhood of the Basilica of San Gerardo Maiella, one of the most important and respected Catholic sanctuaries of Campania and the surrounding areas.
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