New Madrid County is a county located in the Bootheel of the U.S. state of Missouri. As of the 2010 census, the population was 18,956. The largest city and county seat is New Madrid, located on the northern side of the Kentucky Bend in the Mississippi River, where it has formed an oxbow around an exclave of Fulton County, Kentucky. This feature has also been known as New Madrid Bend or Madrid Bend, for the city.
The county was officially organized on October 1, 1812, and is named after Nuevo Madrid, a district located in the region. This area was under Spanish rule following France's cession of Louisiana after being defeated in the Seven Years' War. The Spanish named the district after Madrid, the capital of Spain.
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