The Chicago Union Stock Yards fire occurred from December 22 to December 23, 1910 and resulted in the deaths of twenty-one Chicago Fire Department firemen.
Until September 11, 2001, it was the deadliest building collapse in American history, in terms of firefighter fatalities, although the Texas City Disaster of 1947 killed more firefighters overall. It remains the worst such incident in Chicago history.
Source: Wikipedia.org
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