In december 1614, Tommaso Caccini preaches a sermon in the church Santa Maria Novella of Florence against Galileo and mathematicians who subscribe to the Copernican view which, Caccini avers, is heretical. This was one of the main triggers to bring Galileo Galilei to the Inquisition. Santa Maria Novella was an important place in the conflict between Galileo and the Church. Galileo was denounced from the pulpit of Santa Maria Novella on at least two occasions. Besides the attacs of Caccini, also the Dominican Niccolo Lorini in 1612 zent for him.
The church contains itself many astronomical measuremnt instruments: these instruments were placed on the façade by Dominican Egnatio Danti at the request of of Cosimo I de'' Medici.
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