The Palazzo Mancini is a palazzo in Rome, Italy. From 1737 to 1793 it was the second home of the French Academy in Rome. It is located on Via del Corso, about a block north of Piazza Venezia.
In 1634 Lorenzo Mancini, brother of cardinal Francesco Maria Mancini, married Geronima Mazzarino, sister of cardinal Mazarin. For their wedding celebrations, the old residence of the Mancini family was enlarged by the acquisition of four adjoining houses and a new building designed by the architect Carlo Rainaldi. The work was begun by Lorenzo and completed by Filippo Mancini, duke of Nevers, between 1687 and 1689.
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