San Germán is a municipality located in the southwestern region of Puerto Rico, south of Mayagüez and Maricao, north of Lajas, east of Hormigueros and Cabo Rojo, and west of Sabana Grande. San Germán is spread over eighteen barrios plus San Germán Pueblo . It is both a principal city of the San Germán–Cabo Rojo Metropolitan Statistical Area and the Mayagüez–San Germán–Cabo Rojo Combined Statistical Area.
San Germán is the second oldest city of Puerto Rico, after San Juan. The island of Puerto Rico was once split between the San Juan and the San Germán municipalities. The latter covered the western half of Puerto Rico, and extended from the western shores of the island to Arecibo in the north and Ponce in the south.
The population of San Germán when Alonso Manso was named the first bishop of Puerto Rico in 1511 was "about 50 neighbors".
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