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Ruta desde la Plaza de España hasta el Castillo de los Ángeles y la Ciudad del Vaticano.
La ruta a pie termina en la estación de metro Cipro y continúa en la estación de metro Colosseo.
Después del mediodía, sale un autobús directo '118' cada 20' desde el Coliseo hacia las Catacumbas de San Calixto.
El regreso al Coliseo es igual con el autobús '118'.
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