Großlohra is a municipality in the district of Nordhausen, in Thuringia, Germany, situated on the northern edge of the Hainleite ridge about 20 km southwest of the district capital. It consists of the settlements of Friedrichslohra, Großwenden, Kleinwenden, as well as Münchenlohra with its former convent basilica St. Gangulphus and castle Lohra with its accompanying manor , all of which were united in 1950.
Castle Lohra overlooks the gap between the Dün and Hainleite ridges, being situated on the northwesternmost spur of the latter. Historically, it guarded an important connection between Mühlhausen and the Halle-Kassel trade route in the Wipper valley, whose current incarnation is the Bundesautobahn 38. It was also a strategically important vantage point overlooking the plains between Hainleite and Harz.
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