Otoyol 53 , abbreviated as O-53, also known as Ceyhan-İskenderun Otoyolu , is a toll motorway in Mediterranean Region, Turkey, connecting the Adana-Şanlıurfa Motorway O-52 with İskenderun. The motorway is part of international routes as European route E91 and Asian Highway 84.
The O-53 starts from Ceyhan in Adana Province at the junction of O-52, runs southward to İskenderun South bypassing the city in the east.
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