Anazarbus was an ancient Cilician city. Under the late Roman Empire, it was the capital of Cilicia Secunda. Roman emperor Justin I rebuilt the city in 527 after a strong earthquake hit it. It was destroyed in 1374 by the forces of Mamluk Empire, after their conquest of Armenia.
It was situated in Anatolia in modern Turkey, in the present Çukurova about 15 km west of the main stream of the present Ceyhan River and near its tributary the Sempas Su.
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