The Meredosia National Wildlife Refuge is a 5,255-acre national wildlife refuge located along the Illinois River in Cass County and Morgan County in the U.S. state of Illinois. The refuge is adjacent to Meredosia, Illinois, but is managed by the U.S. Fish and Wildlife Service from a headquarters located in Havana, Illinois.
The Meredosia National Wildlife Refuge is located on a riverine zone, historically wetland, that borders the Illinois River and its flyway for waterfowl. Much of the Refuge is located on a patch of wetland that is still called Meredosia Island although it is now permanently connected to the mainland by drained parcels of former riverbed. To the east of the Refuge is a large shallow lake, Meredosia Lake.
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